| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas
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| Autores: |
Schmitt, Paulina
De Lorgeril, Julien
Gueguen, Yannick
Destoumieux-garzon, Delphine
Bachere, Evelyne
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| Data: |
2012-07
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| Ano: |
2012
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| Palavras-chave: |
Pacific oyster
Bivalve mollusk
Innate immunity
Bactericidal/permeability-increasing protein
Proline-rich peptide
Defensin
Vibrio
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| Resumo: |
Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00093/20382/18267.pdf
DOI:10.1016/j.dci.2012.01.004
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| Editor: |
Elsevier Sci Ltd
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| Relação: |
http://archimer.ifremer.fr/doc/00093/20382/
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| Formato: |
application/pdf
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| Fonte: |
Developmental And Comparative Immunology (0145-305X) (Elsevier Sci Ltd), 2012-07 , Vol. 37 , N. 3-4 , P. 363-370
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| Direitos: |
2012 Elsevier Ltd. All rights reserved.
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